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目的通过Meta分析的方法系统评价细胞色素P4502E1(CYP2E1)基因RsaⅠ/PstⅠ位点多态性与中国人食管癌发病风险的相关性。方法检索PubMed、Embase、CBM、CNKI、VIP和WANFANG数据库中1990年1月1日至2011年11月30日有关CYP2E1基因多态性与食管癌发病风险关系的文献,进行文献筛选、质量评价和数据提取后,采用RevMan5.1软件进行Meta分析。结果最终纳入18篇病例对照研究共19个试验,其中食管癌患者1663例,对照2603例。Meta分析结果显示CYP2E1基因多态性与食管癌的关联有统计学意义[c2vs.c1:OR=0.64,95%CI=0.50～0.81,P=0.0003;c2/c2vs.c1/c1:OR=0.70,95%CI=0.56～0.89,P=0.003;c1/c2vs.c1/c1:OR=0.54,95%CI=0.38～0.75,P=0.0003;c2/c2vs.(c1/c1+c1/c2):OR=0.73,95%CI=0.58～0.92,P=0.008;(c1/c2+c2/c2)vs.c1/c1:OR=0.48,95%CI=0.34～0.70,P=0.0001];汉族的亚组分析结果也显示CYP2E1基因多态性与食管癌的关联有统计学意义[c2vs.c1:OR=0.71,95%CI=0.57～0.89,P=0.002;c2/c2vs.c1/c1:OR=0.75,95%CI=0.59～0.95,P=0.02;c1/c2vs.c1/c1:OR=0.62,95%CI=0.46～0.84,P=0.002;c2/c2vs.(c1/c1+c1/c2):OR=0.78,95%CI=0.61～0.99,P=0.04;(c1/c2+c2/c2)vs.c1/c1:OR=0.56,95%CI=0.40～0.79,P=0.001]。结论对目前相关研究结果的Meta分析显示CYP2E1基因多态性与中国人群食管癌发生风险具有相关性,其RsaⅠ/PstⅠ位点的c2等位基因可能是食管癌的保护或抑制因素。
Objective To evaluate the relationship between the RsaⅠ / PstⅠ polymorphism of cytochrome P4502E1 (CYP2E1) gene and the risk of Chinese esophageal cancer by Meta-analysis. Methods The literature about the relationship between CYP2E1 gene polymorphism and the risk of esophageal cancer in PubMed, Embase, CBM, CNKI, VIP and WANFANG databases from January 1, 1990 to November 30, 2011 was searched. The results of literature review, quality evaluation and After data extraction, RevMan5.1 software was used for meta-analysis. Results A total of 18 trials were included in 18 case-control studies, including 1663 cases of esophageal cancer and 2603 cases of control. Meta analysis showed that there was a significant correlation between CYP2E1 gene polymorphism and esophageal cancer [c2vs.c1: OR = 0.64, 95% CI = 0.50-0.81, P = 0.0003; c2 / c2vs.c1 / c1: OR = 0.70 C1 / c2 vs c1 / c1: OR = 0.54, 95% CI = 0.38-0.75, P = 0.0003; c2 / c2vs. : OR = 0.73, 95% CI = 0.58-0.92, P = 0.008; (c1 / c2 + c2 / c2) vs.c1 / c1: OR = 0.48, 95% CI = 0.34-0.70, P = 0.0001] The subgroup analysis also showed that CYP2E1 gene polymorphism associated with esophageal cancer was statistically significant [c2vs.c1: OR = 0.71, 95% CI = 0.57 ~ 0.89, P = 0.002; c2 / c2vs.c1 / c1: OR = 0.75, 95% CI = 0.59-0.95, P = 0.02; c1 / c2 vs.c1 / c1: OR = 0.62, 95% CI = 0.46-0.84, P = 0.002; c2 / c2vs. /c2):OR=0.78,95%CI=0.61~0.99,P=0.04;(c1/c2+c2/c2)vs.c1/c1:OR=0.56,95%CI=0.40~0.79,P=0.001 ]. Conclusions Meta-analysis of the current research results shows that CYP2E1 gene polymorphism is associated with the risk of esophageal cancer in Chinese population. The c2 allele of RsaⅠ / PstⅠ locus may be the protective or inhibitory factor of esophageal cancer.