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弓形虫病是心脏移植时的并发症之一。在加利福尼亚的斯坦福,发现8例心脏移植者中有7例并发此病,这种感染是较难避免的。其原因可能是由于病人肌肉或其他组织中能存活数年的弓形虫再激活或“复燃”所致。在北美已知35%的正常成人有此虫感染,其体内已具有抗体。Feldman认为,虽然初次传染可以由输入白细胞而发生,但大多数接受器官移植病人的“复燃”是由于采用免疫抑制治疗的结果。作者的经验提供了初次感染的证据,推测是由于供者心肌内能生存的弓形虫转移之故,因为感染与供者/受者
Toxoplasmosis is one of the complications of heart transplantation. At Stanford, California, seven of the eight heart transplant recipients were found to have the disease, and the infection is more difficult to avoid. The reason may be due to reactivation or “rekindling” of Toxoplasma gondii that can survive for years in the patient’s muscle or other tissues. It is known in 35% of normal adults in North America that this worm is infected and has antibodies in its body. Feldman believes that while the initial transmission can occur with the introduction of leukocytes, the majority of patients who have undergone organ transplantation are “rekindled” as a result of immunosuppressive therapy. The authors’ experience provides evidence of an initial infection, presumably due to the transfer of Toxoplasma gondii surviving in the donor’s myocardium because of infection with the donor / recipient