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目的初步了解抗中心体抗体(ACA)在儿童病原感染及自身免疫性疾病中的临床意义。方法收集广州市儿童医院2009年4月至9月19例ACA检测阳性患儿为ACA阳性组、42例ACA阴性为阴性对照组,选取同期常见病原微生物感染及正常儿童为阳性对照组和正常对照组。对4组病原微生物感染指标和其他自身抗体及炎症相关蛋白资料进行统计学分析。结果 ACA阳性存在于自身免疫相关疾病如系统性红斑狼疮(SLE)等16例次(84.2%);感染因素相关疾病7例次(36.8%)。ACA阳性组与阴性对照组间病原微生物感染指标差异无统计学意义(P>0.05);两组间ANA阳性率差异有统计学意义(P<0.001)。阳性对照组、正常对照组与ACA阳性组间病原微生物感染指标差异无统计学意义(P>0.05)。结论儿童ACA常见于免疫性疾病如SLE、川崎病,与机体亢进的自身免疫状态有关,而与以往报道的MP、CP、HSV等病原微生物感染无直接关系。
Objective To understand the clinical significance of anti-centrosome antibodies (ACA) in children with pathogen infection and autoimmune diseases. Methods From April 2009 to September 2009, ACA positive children with ACA test were collected from Children’s Hospital of Guangzhou City. Among the 42 children who were negative for ACA, negative ACA was used as control group. Common pathogenic microbe infection and normal children in the same period were selected as positive control group and normal control group group. Four groups of pathogenic microorganism infection indicators and other autoantibodies and inflammation-related protein data were statistically analyzed. Results There were 16 (84.2%) cases of autoimmunity-related diseases such as systemic lupus erythematosus (SLE) and 7 cases (36.8%) of infection-related diseases. There was no significant difference in pathogenic microorganism infection between ACA positive group and negative control group (P> 0.05). The positive rate of ANA between the two groups was statistically significant (P <0.001). The positive control group, normal control group and ACA positive group showed no significant difference in pathogenic microorganisms (P> 0.05). Conclusion Children ACA is common in autoimmune diseases such as SLE and Kawasaki disease and is associated with the autoimmune state of hyperthyroidism. However, it is not directly related to the previously reported infection of pathogenic microorganisms such as MP, CP and HSV.