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随着肥胖患者不断增多,通过研究小鼠胚胎干细胞向脂肪细胞分化的分子机制,探讨肥胖发生机制已成为研究热点。研究认为,过氧化物酶体增殖物激活受体(PPARγ)、CCAAT增强子结合蛋白(C/EBPα)及脂肪细胞决定和分化依赖因子1和类固醇调控元件结合蛋白(ADD1/SREBP-1c)为前脂肪细胞系向脂肪细胞分化的关键转录因子,其他的调节因子如糖皮质激素(GC)、丝裂原活化蛋白激酶P38(P38MAPK)、生长激素(GH)等大多通过这些关键转录因子发挥诱导或抑制作用。
With the increasing number of obese patients, exploring the molecular mechanism of mouse embryonic stem cells differentiating into adipocytes to investigate the mechanism of obesity has become a hot topic. Studies suggest that peroxisome proliferator-activated receptor (PPARγ), CCAAT enhancer binding protein (C / EBPα), and adipocyte differentiation and differentiation-dependent factor 1 (ADR) and steroid regulatory element binding protein (ADD1 / SREBP-1c) Preadipocyte lines are key transcription factors that differentiate into adipocytes. Other regulators such as glucocorticoids (GCs), mitogen-activated protein kinase P38 (P38MAPK), growth hormone (GH), etc. are mostly induced by these key transcription factors Or inhibitory effect.