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经胃蛋白酶纯化的链球菌血清5型M蛋白(pep M5)是一种超抗原。它刺激人体免疫系统引起免疫应答能力不如葡萄球菌肠毒素(SEB)或链球菌致热肠毒素A和C等超抗原毒素,这可能与细胞因子释放的数量、性质和时相有关。为进一步了解pep M5与人免疫系统的相互作用,作者进行研究,以了解pepM5诱导炎性细胞因子产生的能力。 M蛋白是用M5型A群链球菌经胃蛋白酶有限消化,高压液相色谱法DEAE阴离
The pepsin-purified Streptococcus serotype 5 M protein (pep M5) is a superantigen. It stimulates the immune system to cause immune response than staphylococcal enterotoxin (SEB) or streptococcus pyreticotoxin A and C and other superantigens toxins, which may be related to the quantity, nature and phase of cytokine release. To further understand the interaction of pep M5 with the human immune system, the authors conducted a study to understand pepM5’s ability to induce inflammatory cytokine production. M protein is limited by pepsin digestion with M5 group A streptococcus, high pressure liquid chromatography DEAE anion