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肾小管酸中毒(RTA)是由于先天性或后天性肾小管功能障碍引起的酸碱平衡失常与尿酸化机能低下综合征。以高氯血症性代谢性酸中毒为特征,尿液酸化障碍,pH>6.o0,但肾小球功能正常或仅轻度受损。其致病因素繁多,临床表现复杂,故将一些国内资料加以综合。一、正常尿的酸化过程正常代谢过程中,机体每日氢离子产量约50～70毫当量,为保持机体酸碱平衡,肾脏通过下述三种方式清除等量的净酸负荷。1.近端肾小管对碳酸氢钠的重吸收:近端肾小管细胞中的水和二氧化碳,在碳酸
Renal tubular acidosis (RTA) is a disorder of acid-base balance and uric acid-hypopnysia syndrome due to congenital or acquired tubular dysfunction. To hyperchlorosis metabolic acidosis characterized by urinary acidosis, pH> 6.o0, but glomerular function is normal or only mildly impaired. Its numerous risk factors, clinical manifestations of complex, it will be some domestic information to be integrated. First, the normal process of urine acidification During normal metabolism, the body of hydrogen ion production per day about 50 to 70 milliequivalents, in order to maintain the body’s acid-base balance, the kidneys through the following three ways to clear the same amount of net acid load. 1. proximal tubular reabsorption of sodium bicarbonate: proximal tubular cells in the water and carbon dioxide, carbonated