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很久以前,人们就在试图寻找一种减弱眼外肌功能的药物以治疗斜视。动物实验上所试用药物包括酒精,氟磷酸二异丙酯,金环蛇神经毒素A 等,但由于严重的全身毒性反应,选择性差,抑或作用微弱或短暂,或因是抗原物质等原因而未能应用于临床。肉毒杆菌毒素A 是一种强有力的神经～肌肉联结处阻滞剂无上述药物的许多限制之虞。自1978年Scott 首次成功地引用于临床后,许多国家的学者对此疗法进行了较为广泛的探讨,取得了可喜的成就。本文就最近几年来公开发表的一系列文献对BTXA 的理化
Long ago, people were trying to find a medicine that weakens the function of extraocular muscles to treat strabismus. The drugs tested in animal experiments include alcohol, diisopropyl fluorophosphate, Toxoplasma gondii A, etc., but due to severe systemic toxicity, poor selectivity, or weak or transient effects, or because of antigenic material and other reasons not Can be used in clinical. Botulinum toxin A is a potent neuromuscular blocker without many of the limitations of these drugs. Since Scott’s first successful introduction in the clinic in 1978, scholars from many countries have conducted extensive discussions on this therapy and made gratifying achievements. In this paper, a series of documents published in recent years on the physical and chemical BTXA