论文部分内容阅读
过去,成人接种白喉-破伤风类毒素(DT)后的反应率很高,此与制品中的类毒素剂量和接种者先前的免疫状态有关。后来由于技术的进步,此疫苗有很多改进,主要是类毒素的提纯和标准剂量的确定;白喉类毒素剂量由25Lf单位(絮状反应单位)减至2Lf单位,可以生成足够的抗体,但反应率大为降低。近年由于白喉的爆发导致对成人和儿童二者都进行广泛的DF接种。 1975年秋阿拉斯加散在发生12例白喉,流行病学调查未发现其间的传播关系,接触者中发现大批无症状带菌者,因而刘成人采取DT普遍接种。所用DT制剂为明矾沉淀
In the past, there was a high response rate in adults after diphtheria-tetanus toxoid (DT) inoculation, which was related to the amount of toxoid in the preparation and the vaccination’s previous immunization status. Later, due to technical advances, the vaccine has many improvements, mainly toxoid purification and standard dose determination; diphtheria toxoid dose from 25Lf units (flocculent reaction unit) to 2Lf units, can generate enough antibodies, but the reaction The rate is greatly reduced. In recent years there has been widespread DF vaccination in both adults and children due to the outbreak of diphtheria. Twelve cases of diphtheria were scattered in Alaska in the autumn of 1975. Epidemiological investigation did not find the transmission relations between them. A large number of asymptomatic carriers were found in the contacts, and Liu adults adopted DT universal vaccination. The DT preparation used was alum precipitation