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目的:评价纳络酮联合无创正压机械通气(NIPPV)治疗老年慢性阻塞性肺疾病(COPD)合并Ⅱ型呼吸衰竭的临床疗效。方法:87例60岁以上COPD合并Ⅱ型呼吸衰竭患者,分为治疗组41例和对照组46例,两组均给予常规药物综合治疗和无创正压机械通气治疗,治疗组加用纳络酮治疗。结果:治疗组41例患者,治疗后其动脉血氧分压(PaO2)和二氧化碳分压(PaCO2)较治疗前明显改善(P<0.01);与对照组比较,肺性脑病患者清醒时间缩短(P<0.01)、平均住院天数缩短(P<0.05)、血气改善时间提前(P<0.01)和血气改善程度更好(P<0.05)。结论:纳络酮联合无创正压机械通气是治疗老年COPD合并Ⅱ型呼吸衰竭的一种安全有效的方法。
Objective: To evaluate the clinical efficacy of Naloxone combined with noninvasive positive pressure mechanical ventilation (NIPPV) in the treatment of senile chronic obstructive pulmonary disease (COPD) with type Ⅱ respiratory failure. Methods: A total of 87 patients with COPD and type Ⅱ respiratory failure over the age of 60 were divided into treatment group (n = 41) and control group (n = 46). Both groups were given conventional drug combination therapy and non-invasive positive pressure mechanical ventilation. treatment. Results: After treatment, the PaO2 and PaCO2 of 41 patients in the treatment group were significantly improved compared with that before treatment (P <0.01). Compared with the control group, the patients with pulmonary encephalopathy had shorter awake time P <0.01), shortened average days of hospitalization (P <0.05), improved blood gas earlier (P <0.01) and improved blood gas (P <0.05). Conclusion: Naloxone combined with non-invasive positive pressure mechanical ventilation is a safe and effective method for the treatment of COPD with type Ⅱ respiratory failure.