论文部分内容阅读
胰腺癌的死亡率很高,5年生存率少于5％。对不能手术的病人尚无有效的治疗,化疗和放疗能减轻症状,但对5年生存率没有明显影响。为改善胰腺癌患者的预后,近年来在化疗、放疗和手术结合方面作了许多研究。 手术切除患者应用术前、术中和术后放疗对改善生存期超过单纯手术。手术中放疗可控制局部复发。经肝动脉或门静脉的肝灌注化疗可改善3年生存期。 对不能手术切除患者,常规放疗大多无效,用较高的剂量(50～70Gy)可使中位生存期延长。间质植入放疗的效果还需在随机研究中评价。化疗与放疗结合及
Pancreatic cancer has a high mortality rate, with a 5-year survival rate of less than 5%. There is no effective treatment for inoperable patients. Chemotherapy and radiotherapy can relieve symptoms, but there is no significant effect on 5-year survival rate. In order to improve the prognosis of patients with pancreatic cancer, many studies have been done in recent years in the combination of chemotherapy, radiotherapy and surgery. Surgical resection of patients with preoperative, intraoperative, and postoperative radiotherapy improved survival over surgery alone. Radiotherapy during surgery can control local recurrence. Hepatic perfusion via hepatic artery or portal vein can improve 3-year survival. For patients who cannot be surgically resected, conventional radiotherapy is mostly ineffective, with a higher dose (50 to 70 Gy) to extend the median survival. The effect of interstitial implanted radiotherapy needs to be evaluated in a randomized study. Combination of chemotherapy and radiotherapy