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两节头的硬明胶胶囊是一种适宜的单剂量药物容器,它可以防止在吞咽时发生恶味,并且在到达胃以后可以迅速溶解。高速填装设备的发展和价廉物美的胶囊的利用促使人们恢复了对于胶囊作为一种剂量型的兴趣。胶囊是精制的动物明胶制成的,可以含有极少量的其他物质如染料或防腐剂;但是,硬胶囊的物理性质主要就是原料明胶的性质。明胶一般含有9—12％的水份,但是,水份的含量随着环境可有约4％到16％的变化。可以想象到正常胶囊中所含的水能够转移而对胶囊内容物呈现有害的作用。此外,如胶囊内容物是引湿性的,则大气的水蒸汽可以扩散穿过胶囊。明胶不能用正常的干燥方法完全无水,如果达到含水量
A two-head hard gelatin capsule is a suitable single-dose drug container that prevents malodour during swallowing and dissolves quickly upon reaching the stomach. The development of high-speed filling equipment and the use of inexpensive capsules have prompted the restoration of interest in capsules as a dosage form. Capsules are made from refined animal gelatin and may contain very small amounts of other substances such as dyes or preservatives; however, the physical properties of hard gelatin capsules are primarily those of raw gelatin. Gelatin typically contains 9-12% moisture, however, the moisture content can vary from about 4% to 16% depending on the environment. It is conceivable that the water contained in the normal capsule can be transferred to have a detrimental effect on the capsule contents. In addition, if the capsule contents are hygroscopic, atmospheric water vapor can diffuse through the capsule. Gelatin can not be completely dehydrated with normal drying methods, if it reaches a water content