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23例消化性溃疡,包括14例十二指肠溃疡、9例胃溃疡,经过6周甲氰咪胍治疗(1g/d),有20例(89%)溃疡愈合,胃内 pH 值从治疗前的1.72±2.1升高至治疗后的5.34±0.43(p<0.001),最大胃酸排泌量(MAO)降低73%,高峰胃酸(PAO)降低36%,每毫升胃液中细菌平均浓度从治疗前的 log_(10)0.82±0.68显著升高至治疗后的 log_(10)4.91±0.59(p<0.001)。甲氰咪胍治疗6周后,胃液中4例无菌,14例有上呼吸道型菌群,5例有粪便型菌群或与上呼吸道型菌群并存。23例中4例有念珠菌。细菌数量与基础 pH 值和基础酸排泌量(BAO)密切相关,与
Twenty-three (23%) peptic ulcers, including 14 duodenal ulcers and 9 gastric ulcers, had healing of 20 cases (89%) of ulcers after 6 weeks of cimetidine treatment (1 g / d) The former 1.72 ± 2.1 increased to 5.34 ± 0.43 (p <0.001) after treatment, the maximal gastric acid excretion (MAO) decreased 73%, the peak acid (PAO) decreased 36%, the average concentration of bacteria per ml of gastric juice from the treatment Before log_ (10) 0.82 ± 0.68 was significantly increased to log_ (10) 4.91 ± 0.59 (p <0.001) after treatment. After 6 weeks of cimetidine treatment, 4 cases of gastric juice were sterile, 14 cases of upper respiratory tract flora, and 5 cases of fecal or coexisting with upper respiratory tract flora. Candidiasis was found in 4 of 23 cases. The number of bacteria is closely related to basal pH and basal acid excretion (BAO)