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乙型肝炎病毒(H BV)感染在临床可产生不同的肝脏疾病谱,发生轻重悬殊的肝脏疾病。宿主对H BV抗原的免疫应答是肝细胞损害的可能机制,但宿主应答不同的原因迄今未充分阐明。近年分子病毒学的进展,发现H BV变异与临床关系密切,其中有关H BV前C区终28变异研究最多。1989年英国学者
Hepatitis B virus (H BV) infection clinically can produce different spectrum of liver disease, the occurrence of serious disease of liver disease. The host’s immune response to H BV antigen is a possible mechanism of hepatocellular damage, but the reasons for the different host responses have so far not been fully elucidated. In recent years, the progress of molecular virology and found that the variation of H BV is closely related to the clinic, of which the study of the last 28 mutations in pre-C region of H BV has the most research. British scholar in 1989