论文部分内容阅读
Combretastatin A4(CA4)为非洲灌木矮柳树(Combretum caffrum)树皮植物中分离的一种具有抗肿瘤活性的化合物,为微管蛋白抑制剂。本文综述了近几年来对CA4类似物研究的新进展,其主要方法集中在对CA4中的A环、B环及其骨架结构的修饰。
Combretastatin A4 (CA4) is an anti-tumor compound isolated from bark plants of the African shrubs Combretum caffrum and is a tubulin inhibitor. This review summarizes recent advances in the study of analogues of CA4. The main methods are focused on the modification of the A ring, the B ring and their backbone structures in CA4.