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目的探讨血清和肽素及N末端脑钠素原对急性脑梗死患者诊断的临床价值。方法选取84例急性脑梗死患者作为疾病组对象,根据NIHSS评分分为轻症组(n=55)和重症组(n=29),另选择同期健康体检者90例作为对照组,收集并比较2组对象的一般资料,分析不同病情、不同时间点患者血清和肽素及N末端脑钠素原的水平。结果轻症组、重症组的血清和肽素及N末端脑钠素原水平均高于对照组,差异具有统计学意义(P<0.05);重症组24 h、7 d、14 d的和血清肽素水平均显著高于轻症组;重症组24 h、7 d的N末端脑钠素原水平均显著高于轻症组,差异均有统计学意义(P<0.05);至14 d时,2组的N末端脑钠素原水平差异无统计学意义(P>0.05)。结论急性脑梗死患者的血清和肽素及N末端脑钠素原均显著升高,其浓度水平与病情严重程度紧密相关。
Objective To investigate the clinical value of serum copeptin and N-terminal pro-brain natriuretic peptide in the diagnosis of patients with acute cerebral infarction. Methods Eighty-four patients with acute cerebral infarction were selected as the disease group. According to the NIHSS score, the patients were divided into mild group (n = 55) and severe group (n = 29). Another 90 healthy subjects were selected as the control group. 2 groups of general information of the object, analysis of different conditions, at different time points in patients with serum copeptin and N-terminal pro brain natriuretic peptide levels. Results The levels of serum copeptin and N-terminal pro-brain natriuretic peptide were significantly higher in the mild and severe cases than those in the control group (P <0.05). Serum levels of serum peptides in severe group at 24 h, 7 d and 14 d The level of N-terminal pro-brain natriuretic peptide in severe group at 24 h and 7 d was significantly higher than that in mild group (P <0.05). At 14 d, the level of N-terminal pro-brain natriuretic peptide in severe group was significantly higher than that of mild group There was no significant difference in N-terminal pro-brain natriuretic peptide between the two groups (P> 0.05). Conclusions Serum copeptin and N-terminal pro-brain natriuretic peptide were significantly increased in patients with acute cerebral infarction. The level of serum proBNP is closely related to the severity of the disease.