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目的探讨不同化疗方案联合放疗治疗局部晚期鼻咽癌的疗效。方法80例Ⅲ、Ⅳa期鼻咽部低分化鳞癌患者,随机分为研究组和对照组两组,每组40例。研究组用泰索帝(TXT)+草酸铂(L-OHP)化疗结合放疗;对照组用顺铂(DDP)+甲酰四氢叶酸钙(CF)+5-氟脲嘧啶(5-Fu)化疗结合放疗。放疗为根治性,化疗4～5个周期,每3周为1个周期。结果两组鼻咽部原发灶及颈部淋巴结消退情况相似,差异无统计学意义(P>0.05),但研究组恶心呕吐及黏膜反应的发生率明显低于对照组,差异有统计学意义(P<0.05)。结论TXT+L-OHP方案联合放疗治疗晚期鼻咽癌的近期疗效与DDP+CF+5-Fu方案相似,但不良反应明显减少。
Objective To investigate the curative effect of different chemotherapy combined with radiotherapy in the treatment of locally advanced nasopharyngeal carcinoma. Methods Eighty patients with stage Ⅲ and Ⅳa nasopharyngeal poorly differentiated squamous cell carcinoma were randomly divided into study group and control group, 40 cases in each group. The study group was treated with TXT and L-OHP combined with radiotherapy. The control group was treated with DDP plus 5-Fu, Chemotherapy combined with radiotherapy. Radiotherapy is radical, chemotherapy 4 to 5 cycles, every 3 weeks for a cycle. Results The regression of nasopharyngeal primary lesions and cervical lymph nodes were similar between the two groups (P> 0.05), but the incidence of nausea and vomiting and mucosal reaction in the study group was significantly lower than that in the control group (P <0.05). Conclusions The short-term efficacy of TXT + L-OHP combined with radiotherapy in the treatment of advanced nasopharyngeal carcinoma is similar to that of DDP + CF + 5-Fu regimen, but the adverse reaction is significantly reduced.