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目的 :采用改良的酚红含量测定法观察中药枳壳及辛弗林对小鼠胃肠运动功能的影响。方法 :将 NIH小鼠 30只随机分为三组 ,分别给予枳壳水煎剂、辛弗林和蒸馏水 (均为 0 .2 5m L/1 0 g) ,并于 3日后采用改良的酚红含量测定法对小鼠的胃肠运动情况进行观察分析。结果 :枳壳水煎剂和辛弗林对正常小鼠胃排空无影响 ,但能促进正常小鼠小肠推进 ;同时两者皆能拮抗肾上腺素所致的小鼠胃排空、小肠推进抑制 ,但对阿托品所致的小鼠胃排空、小肠推进抑制没有明显影响 ;并且枳壳水煎剂还能微弱加强新斯的明所致的小鼠胃排空、小肠推进亢进 ,辛弗林则对其没影响。结论 :枳壳水煎剂及辛弗林有一定的促胃肠动力作用 ,其作用机理可能主要与胆碱能系统有关
Objective : To observe the effect of Chinese wolfberry shell and synephrine on gastrointestinal motility in mice by modified phenol red assay. METHODS: Thirty NIH mice were randomly divided into three groups and given water decoction, synephrine and distilled water (both 0.25 ml/l0 g), respectively, and modified phenol red was used after 3 days. The content assay measures the gastrointestinal motility in mice. Results: The decoction of decoction of shellfish and synephrine had no effect on gastric emptying in normal mice, but it could promote the advancement of small intestine in normal mice. Both of them could antagonize the gastric emptying and suppression of intestinal propulsion induced by epinephrine in mice. However, there was no significant effect on atropine-induced suppression of gastric emptying and small intestine advancing in mice; and decoction of water extract from the shell of seaweed could also slightly enhance neostigmine-induced mouse gastric emptying and small intestine advancing hyperactivity, synephrine It has no effect on it. Conclusion : The decoction of the shellfish and synephrine have a certain role in promoting gastrointestinal motility, and its mechanism of action may be mainly related to the cholinergic system.