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目前已经鉴定出17种类泛素蛋白(ubiquitin-like proteins,UBLs),这些蛋白与底物的结合方式与泛素相似.根据进化特征,可将UBLs分为9类,分别为:NEDD8、SUMO、ISG15、FUB1、FAT10、Atg8、Atg12、Urm1和UFM1.NEDD8是目前研究最多的UBLs之一,与泛素的氨基酸序列具有高度相似性.NEDD化修饰是一种动态的可逆蛋白质翻译后修饰方式,可以将NEDD8共价结合到靶蛋白之上,也可以将NEDD8从靶蛋白上去除.NEDD化修饰对蛋白功能具有重要的调节作用,如改变蛋白质的空间构象、阻碍底物与其它蛋白质的相互作用和招募与NEDD8相互作用的蛋白等.最新研究表明,NEDD化与肿瘤的发生发展密切相关,但具体的机制还不清楚.本文将就NEDD化修饰在肿瘤发展过程中的作用机制做一综述.
Up to date, 17 kinds of ubiquitin-like proteins (UBLs) have been identified and their binding to substrate is similar to that of ubiquitin.According to the evolutionary characteristics, UBLs can be divided into 9 classes: NEDD8, SUMO, ISG15, FUB1, FAT10, Atg8, Atg12, Urm1 and UFM1.NEDD8 is one of the most studied UBLs and has a high similarity with the amino acid sequence of ubiquitin.NEDD modification is a dynamic reversible protein post-translational modification, NEDD8 can be covalently attached to the target protein and NEDD8 can also be removed from the target protein.NEDD modification plays an important regulatory role in the function of the protein such as altering the spatial conformation of the protein and blocking the interaction of the substrate with other proteins And recruitment of proteins that interact with NEDD8, etc. Recent studies have shown that NEDD is closely related to the occurrence and development of tumors, but the specific mechanism is not clear.In this paper, the mechanism of NEDD modification in tumor development is reviewed.