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AIM To compare the combinative andindividual effect of acarbose and gymnemic acid(GA) on maltose absorption and hydrolysis insmall intestine to determine whether nutrientcontrol in diabetic care can be improved bycombination of them.METHODS The absorption and hydrolysis ofmaltose were studied by cyclic perfusion ofintestinal loops in situ and motility of theintestine was recorded with the intestinal ring invitro using Wistar rats.RESULTS The total inhibitory rate of maltoseabsorption was improved by the combination ofGA (0.1g/L-1.0g/L) and acarbose(0.1 mmol/L-2.0mmol/L) throughout theireffective duration (P<0.05, U test of Mann-Whitney), although the improvement only couldbe seen at a low dosage during the first hour.With the combination, inhibitory duration ofacarbose on maltose absorption was prolongedto 3 h and the inhibitory effect onset of GA wasfastened to 15min. GA suppressed the intestinalmobility with a good correlation (r=0.98) to theinhibitory effect of GA on maltose absorptionand the inhibitory effect of 2 mmol/L (highdose) acarbose on maltose hydrolysis was dualmodulated by 1 g/L GA in vivo indicating thatthe combined effects involved the functionalalteration of intestinal barriers.CONCLUSION There are augmented effects ofacarbose and GA, which involve pre-cellular andparacellular barriers. Diabetic care can beimproved by employing the combination.
AIM To compare the combinative and intimate effect of acarbose and gymnemic acid (GA) on maltose absorption and hydrolysis insmall intestine determine to nutrient control in diabetic care can be improved by combination of them. METHODS The absorption and hydrolysis of maltose were studied by cyclic perfusion of piping loops in situ and motility of theintestine was recorded with the intestinal ring invitro using Wistar rats .RESULTS The total inhibitory rate of maltoseabsorption was improved by the combination ofGA (0.1 g / L - 1.0 g / L) and acarbose (0.1 mmol / L - 2.0 mmol / L) throughout theireffective duration (P <0.05, U test of Mann-Whitney), although the improvement only could be seen at a low dosage during the first hour .With the combination, inhibitory duration ofacarbose on maltose absorption was prolongedto 3 h and the inhibitory effect onset of GA wasfastened to 15 min. GA suppressed the intestinal motility with a good correlation (r = 0.98) to the inhibition effect of GA on maltose absorpt ion and the inhibitory effect of 2 mmol / L (high dose) acarbose on maltose hydrolysis was dualmodulated by 1 g / L GA in vivo indicating that the combined effects involved the functionalalteration of intestinal barriers. CONCLUSION There are augmented effects of acarbose and GA, which comprising pre- Diabetic care can be treated implanted by employing the combination.