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目的 :临测近期本院新生儿败血症血培养细菌株及其耐药情况。方法 :取 1999年～ 2 0 0 0年新生儿科败血症病例的血培养标本共获细菌 12 9株。用VITEK -AMS鉴定菌株种属 ,K -B法作抗生素耐药试验 ,按NCCLS标准判断结果。结果 :表葡菌 37株 (MRSE占 5 1.4 % ) ,其他CNS 4 6株 (耐甲氧西林株 71.7% ) ,金葡菌 17株 (MRSA 4 7.1% ) ,葡萄球菌几乎全部对青霉素耐药 ,对红霉素耐药率超过 5 0 % ,对万古霉素、亚胺培南及环丙沙星敏感率高。G -菌对氨苄青霉素及庆大霉素耐药率高。未测出ESBLs。结论 :本院新生儿科细菌耐药情况已相当严重 ,抗感染疗法应尽可能以药物监测为依据。
Objective: To test the recent blood culture of neonatal septicemia bacterial strains and their drug resistance. Methods: A total of 129 bacteria were collected from blood culture samples of neonatal septicemia from 1999 to 2000. VITEK-AMS strains were identified strains, K-B method for antibiotic resistance test, according to NCCLS criteria to determine the results. Results: Staphylococcus epidermidis 37 strains (MRSE accounted for 5 1.4%), other CNS 4 6 strains (methicillin-resistant strains 71.7%), Staphylococcus aureus 17 strains (MRSA 4 7.1%), staphylococci almost entirely resistant to penicillin , Resistant to erythromycin more than 50%, high sensitivity to vancomycin, imipenem and ciprofloxacin. G - bacteria resistant to ampicillin and gentamicin. No ESBLs were detected. Conclusion: The drug resistance of neonatal bacteria in our hospital has been quite serious. Anti-infective therapy should be based on drug monitoring as much as possible.