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目的探讨大剂量常规输血及去白细胞输血的临床效果。方法收集行大剂量输血治疗的120例住院患者的临床资料,将常规输血的60例患者作为对照组,去白细胞输血的60例患者作为观察组,分别统计两组患者输血前、输血后24h、72h血清肝功能相关指标(丙氨酸氨基转移酶、天门冬氨酸氨基转移酶、总胆红素)、钙离子、钾离子等的变化,统计非溶血性发热反应(FNHTR)发生率,均行统计学对比。结果两组患者输血前各项血清学检查指标较为接近,无统计学意义(P>0.05)。输血24h后,观察组患者GTP(35.1±5.0)U/L、GOT(60.4±11.9)U/L,TB(14.2±3.2)μmol/L,Ca~(2+)(2.2±0.3)mmol/L,K+(4.8±0.6)mmol/L,明显低于对照组(P<0.05),术后72h两组患者血清学检查指标较为接近,无统计学意义(P>0.05)。观察组患者共发生非溶血性发热反应2例,发生率3.3%,对照组为14例,发生率23.3%,二者相比差异存在统计学意义(P<0.05)。结论大剂量常规输血及去白细胞输血会引起不同程度肝功能指标的损伤,但常规输血造成损伤程度明显高于去白细胞输血,去白细胞输血能明显降低非溶血发热反应的发生率,有效保证了输血效果。
Objective To investigate the clinical effects of high-dose conventional blood transfusion and leukocyte transfusion. Methods The clinical data of 120 inpatients receiving high-dose blood transfusion were collected. Sixty patients with routine blood transfusion were selected as the control group and 60 patients with leukocyte transfusion as the observation group. Before transfusion, 72h serum related indicators of liver function (alanine aminotransferase, aspartate aminotransferase, total bilirubin), calcium, potassium and other changes, statistics non-hemolytic fever response (FNHTR) incidence, both Statistical comparison. Results Before the blood transfusion, the serological indexes of two groups were close, with no statistical significance (P> 0.05). After transfusion for 24 hours, the GTP level in the observation group was 35.1 ± 5.0 U / L, the GOT 60.2 ± 11.9 U / L, L, K + (4.8 ± 0.6) mmol / L, respectively, which were significantly lower than those in the control group (P <0.05). Serological tests were similar between the two groups at 72h postoperatively, with no statistical significance (P> 0.05). There were 2 cases of non-hemolytic fever in the observation group, the incidence was 3.3%, while the control group was 14 cases, the incidence was 23.3%. There was significant difference between the two groups (P <0.05). Conclusion High-dose conventional blood transfusion and leukocyte transfusion will cause different degrees of liver function damage, but the damage caused by routine blood transfusion is significantly higher than leukocyte transfusion, leukocyte transfusion can significantly reduce the incidence of non-hemolytic fever response, effectively ensure the blood transfusion effect.