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目的观察新辅助化疗前后宫颈癌组织VEGF-C的表达和LMVD的变化。方法选取浸润性宫颈鳞癌化疗前宫颈活检组织及化疗后手术的标本蜡块72份(36对),测定其新辅助化疗(NACT)前后组织标本中VEGF-C的表达水平及LMVD的变化,对两者在NACT前后的变化及NACT疗效进行统计学分析。结果 36例宫颈鳞癌NACT的有效率为88.9%,临床有效组中化疗后VEGF-C的表达水平及LMVD值明显低于化疗前,差异有统计学意义(P<0.05)。结论紫杉醇与卡铂(TC)方案的静脉化疗具有较高的临床应用价值。可考虑将VEGF-C和LMVD作为预测NACT效果的参考指标。
Objective To observe the expression of VEGF-C and LMVD in cervical cancer before and after neoadjuvant chemotherapy. Methods Seventy-two (36) paraffin sections of invasive cervical squamous cell carcinoma before operation and cervical cancer after chemotherapy were collected to determine the expression of VEGF-C and LMVD in neoadjuvant chemotherapy (NACT) The changes of both before and after NACT and the efficacy of NACT were statistically analyzed. Results The effective rate of NACT in 36 cases of cervical squamous cell carcinoma was 88.9%. The expression of VEGF-C and LMVD in the clinically effective group after chemotherapy were significantly lower than those before chemotherapy (P <0.05). Conclusion Paclitaxel and carboplatin (TC) venous chemotherapy has a high clinical value. VEGF-C and LMVD can be considered as a reference for predicting NACT efficacy.