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目的探讨抗中性粒细胞抗体(ANCA)在川崎病(KD)中的临床意义。方法对广州市儿童医院2005-11-01—2006-11-01收治的98例KD患儿血清进行ANCA检测,分析KD中ANCA的阳性率,ANCA与静脉注射丙种球蛋白(IVIG)敏感度、冠状动脉损害程度的关系。结果ANCA在KD患儿中阳性率为69.4%;KD中ANCA阳性组和ANCA阴性组两组间对IVIG的敏感性差异无统计学意义(P>0.05);而ANCA阳性患儿冠状动脉损害程度重于ANCA阴性患儿(P<0.05),差异有统计学意义。结论ANCA在KD发生冠状动脉损害的病理发生发展中起一定的作用,可作为临床中KD发生冠状动脉损害的一项预警的实验室指标。
Objective To investigate the clinical significance of anti-neutrophil antibody (ANCA) in Kawasaki disease (KD). Methods A total of 98 children with KD admitted to Guangzhou Children’s Hospital from January 2005 to January 2006 were retrospectively analyzed. The ANCA positive rate in KD, ANCA and IVIG sensitivity were analyzed. Coronary artery damage degree of the relationship. Results The positive rate of ANCA in children with KD was 69.4%. There was no significant difference in the sensitivity to IVIG between ANCA positive group and ANCA negative group in KD (P> 0.05). However, the ANCA-positive children had less coronary artery lesion Heavier than ANCA-negative children (P <0.05), the difference was statistically significant. Conclusion ANCA plays a certain role in the pathogenesis of coronary artery lesion in KD and may be used as an early warning laboratory indicator of coronary artery lesion in KD.