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目的探讨妊高征患者尿微量白蛋白(Microalbum inuria,MA)、血清胱抑素C(CysC)与血清尿素(Urea)、肌酐(Cr)、尿酸(UA)联合检测的临床意义。方法对50例正常妊娠晚期妇女及65例妊高征患者测定血清中胱抑素C与其他肾功能指标;同时检测尿MA并进行分析比较。结果妊高征患者各指标血清值较对照组增高有统计学意义(P<0.05)。其中重度妊高征患者的各指标血清值较轻度、中度妊高征明显增高(P<0.01),胱抑素C与微量白蛋白检测值对重度妊高征肾损害有很好的阳性预测率。结论尿MA和血清CysC具有较好的早期肾损伤诊断价值,在重度的妊高征中有明显变化,与其他肾功能指标联合能灵敏反映重度妊高征患者早期肾损害。
Objective To investigate the clinical significance of microalbuminuria (MA), serum cystatin C (CysC) and serum urea (Urea), creatinine (Cr) and uric acid (UA) in patients with pregnancy induced hypertension. Methods Serum levels of Cystatin C and other renal function indexes were measured in 50 normal pregnant women and 65 cases of pregnancy induced hypertension. Urinary MA was also measured and compared. Results The serum levels of each index in patients with PIH were significantly higher than those in control group (P <0.05). Serum levels of each index of patients with severe PIH were more moderate and moderate PIH was significantly higher (P <0.01), cystatin C and microalbumin values of positive for severe PIH Forecast rate. Conclusions Urine MA and serum CysC have good diagnostic value of early renal injury and have significant changes in severe PIH. Combined with other renal function indexes, urine MA and serum CysC can sensitively reflect the early renal damage in patients with severe PIH.