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对６８例狼疮性肾炎（ＬＮ）患者行肾活检检查，以定性、定量的方法观察了其小管间质损害程度、间质容量变化及肾小球病变各自对狼疮性肾炎肾功能状态的影响。结果发现：（１）伴有明显肾间质损害及肾功能异常者，肾间质容量（Ⅳ）明显增加（３４．７±１４．３％ｖｓ１４．８±４．８％△Ⅳ为２１．９±１０．９％）；（２）肾间质容量变化与肾功能改变之间呈明显相关关系；（３）不同的肾小球病变类型、肾小球病变活动性指数及有无ＩｇＧ在小管基膜上沉积对Ⅳ及肾功能均无明显影响。提示肾间质容量改变可以直接反映肾小管间质损害程度乃至肾功能的变化。在ＬＮ伴明显肾间质损害时，肾功能的变化主要与肾小管间质改变程度有关，而与同期存在的肾小球病变类型、严重程度及活动性关系不大。Ⅳ的定量分析可作为临床判断肾脏损害程度及功能状态的一项颇有价值的指标。
Sixty-eight patients with lupus nephritis (LN) underwent renal biopsy. The effects of interstitial tubulointerstitial damage, interstitial volume changes and glomerular lesions on the renal function of lupus nephritis were observed by qualitative and quantitative methods. The results showed that: (1) The interstitial volume (Ⅳ) significantly increased in patients with obvious renal interstitial damage and abnormal renal function (34.7 ± 14.3% vs14.8 ± 4.8% △ Ⅳ). 9 ± 10.9%). (2) There was a significant correlation between the changes of renal interstitial volume and renal function. (3) The types of glomerular lesions, glomerular lesions activity index and the presence or absence of IgG Tubule deposition on the basement membrane and renal function had no significant effect. Prompted changes in renal interstitial volume can directly reflect the degree of tubulointerstitial damage and changes in renal function. When LN with obvious renal interstitial damage, the changes of renal function were mainly related to the degree of tubulointerstitial changes, but not with the type, severity and activity of glomerular lesions in the same period. Quantitative analysis of Ⅳ can be used as a valuable indicator of the degree of renal damage and functional status in clinical judgment.