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目的探讨血管紧张素原(ATG)基因多态性及体重指数与高血压的关系。方法采用聚合酶链反应结合限制性内切酶消化,对72例原发性高血压患者和78例血压正常者血管紧张素原的M235T基因多态性进行检测。结果高血压组收缩压、体重指数和血管紧张素原水平均高于正常对照组(P<0.05);高血压组与对照组的MM、MT和TT基因型频率分别为0.347、0.319、0.333,0.564、0.244、0.192,差异明显(P<0.05),TT基因型患高血压的相对危险最高。调整多种混杂因素后,Logistic回归分析示T等位基因和体重指数均不同程度的增加了高血压患病的危险性,同时二者存在着协同作用。结论T等位基因、体重指数是预测高血压危险性的有效指标,且二者存在协同效应。控制体重可以有效地防治高血压。
Objective To investigate the relationship between angiotensinogen (ATG) gene polymorphism and body mass index (HbA1c) and hypertension. Methods Polymerase chain reaction (PCR) combined with restriction endonuclease digestion was used to detect the M235T polymorphism of angiotensinogen in 72 patients with essential hypertension and 78 patients with normotension. Results The systolic blood pressure, body mass index and angiotensinogen level in hypertension group were higher than those in normal control group (P <0.05). The frequencies of MM, MT and TT genotypes in hypertension group and control group were 0.347,0.319,0.333,0.564 , 0.244,0.192, the difference was significant (P <0.05), TT genotype had the highest relative risk of hypertension. After adjusting for a variety of confounding factors, Logistic regression analysis showed that the T allele and body mass index all increased the risk of hypertension in varying degrees, and synergistic effects existed between the two. Conclusion The T allele and body mass index are effective indicators for predicting the risk of hypertension, and there is a synergistic effect between them. Weight control can effectively prevent and treat high blood pressure.