论文部分内容阅读
目的：探讨Ｆａｓ－ＦａｓＬ系统在急性病毒性肝炎发病中的作用。方法：采用免疫组织化学技术对３８例急性乙型肝炎患者肝组织中的Ｆａｓ和ＦａｓＬ表达进行检测，并与１０例正常肝组织作对照。结果：３８例急性乙型肝炎肝组织中的Ｆａｓ和ＦａｓＬ表达的检出率分别为５５．３％（２１／３８）和６０．５％（２３／３８）；正常对照、急乙肝轻型和较重型三组之间其肝组织Ｆａｓ和ＦａｓＬ的表达存在显著性差异（Ｐ＜０．０１或Ｐ＜０．００５），并且，急性乙肝较重型其Ｆａｓ和ＦａｓＬ表达明显比轻型增强，两者比较均有显著性差异（Ｐ＜０．０１）。结论：由ＣＴＬ－Ｆａｓ－ＦａｓＬ系统介导的肝细胞凋亡在急性乙型肝炎的发病中可能起了较重要的作用
Objective: To investigate the role of Fas-FasL in the pathogenesis of acute viral hepatitis. Methods: The expression of Fas and FasL in liver tissues of 38 patients with acute hepatitis B were detected by immunohistochemistry and compared with 10 normal liver tissues. Results: The positive rates of Fas and FasL in 38 cases of acute hepatitis B were 55.3% (21/38) and 60.5% (23/38), respectively. There were significant differences in the expression of Fas and FasL in the liver tissues between the three groups (P <0.01 or P <0.005), and the expression of Fas and FasL in the severe hepatitis B group was significantly higher than that of the light group There was significant difference (P <0.01). Conclusions: Hepatocyte apoptosis mediated by CTL-Fas-FasL system may play a more important role in the pathogenesis of acute hepatitis B