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目的 探讨几种药物对血小板活化功能的影响。方法 将 44例脑梗死患者随机分成 3组 :A组 15例予盐酸丁咯地尔 0 .2 ,B组 15例予葛根素 0 .4,C组 14例予三七总皂甙 0 .4,均加入生理盐水 2 5 0ml静脉滴注 ,1次·d-1,共用 14d。在治疗前后采用流式细胞术 (FCM)对患者血小板α -颗粒膜蛋白 (CD62P)和凝血酶敏感蛋白 (TSP)进行测定。结果 B组与C组治疗后与治疗前比较CD62P与TSP均明显降低 (P <0 .0 5 ) ,而A组治疗后与治疗前比较CD62P与TSP均无明显变化(P >0 .0 5 )。结论 葛根素与三七总皂甙对血小板活化功能有明显抑制作用 ,而盐酸丁咯地尔则未见影响
Objective To investigate the effects of several drugs on platelet activation. Methods Forty-four patients with cerebral infarction were randomly divided into three groups: A group of 15 cases buflomedil hydrochloride 0.2, B group 15 cases of puerarin 0.4, C group 14 cases of notoginsenoside 0.4, Were added 250 ml normal saline intravenous infusion, 1 · d-1, shared 14d. Platelet α - granule membrane protein (CD62P) and thrombin - sensitive protein (TSP) were measured by flow cytometry (FCM) before and after treatment. Results The levels of CD62P and TSP in group B and group C after treatment were significantly lower than those before treatment (P <0.05), while there was no significant difference between group A and group before treatment (P> 0.05) ). Conclusion Puerarin and Panax notoginseng have significant inhibitory effects on platelet activation, while buflomedil hydrochloride has no effect