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目的探讨尿酸干预治疗对高尿酸血症合并糖尿病前期患者肾脏损害的影响。方法选择2008年2月-2011年8月在院诊治的男性无症状高尿酸血症合并糖尿病前期患者50例,给予低嘌呤饮食联合降尿酸药物干预治疗;随访1年,比较治疗前后尿微尿白蛋白(MAU)、血清胱抑素C(Cys C)、尿酸和空腹血糖(FPG)。结果治疗前后尿酸分别为(509.40±36.00)、(340.00±39.00)μmol/L,FPG分别为(6.78±0.21)、(5.75±0.65)mmol/L,MAU分别为(45.60±18.30)、(26.30±10.50)mg/L,Cys C分别为(1.36±0.15)、(0.89±0.33)mg/L,治疗后各指标均较治疗前降低,差异有统计学意义(P<0.05)。结论血尿酸干预治疗可降低高尿酸血症合并糖尿病前期患者的肾脏损害,并可降低其FPG水平。
Objective To investigate the effects of uric acid intervention on renal damage in patients with hyperuricemia and pre-diabetes. Methods Fifty patients with asymptomatic hyperuricemia and pre-diabetes in our hospital from February 2008 to August 2011 were treated with low-purine diet combined with uric acid lowering drugs. One year follow-up was performed to compare the urine micro-urine Albumin (MAU), serum cystatin C (Cys C), uric acid and fasting blood glucose (FPG). Results The levels of uric acid were (509.40 ± 36.00) and (340.00 ± 39.00) μmol / L before and after treatment. The FPG were (6.78 ± 0.21) and (5.75 ± 0.65) mmol / L and MAU were (45.60 ± 18.30 and ± 10.50) mg / L and Cys C were (1.36 ± 0.15) and (0.89 ± 0.33) mg / L, respectively. All the indexes were significantly lower than those before treatment (P <0.05). Conclusion Serum uric acid intervention can reduce renal damage in patients with hyperuricemia and pre-diabetes, and reduce FPG levels.