论文部分内容阅读
目的探讨检测血清Cystatin C对早期发现过敏性紫癜患者肾功能损害的意义。方法测定83例过敏性紫癜患者的24h肌酐清除率(24h CCr),血清肌酐(SCr)以及血清Cystatin C(Cys C)水平,并以CCr﹤80ml/min/1.73m2作为肾功能损害诊断标准,采用χ2检验、相关性分析和ROC曲线分析CysC的诊断价值。结果 83例患者中共32例出现CCr下降,其中Cys C水平上升有27例,而仅有13例SCr出现异常。Cys C对CCr的评估效能优于SCr(P﹤0.05),相关性分析提示在过敏性紫癜患者中,Cys C与SCr和CCr均有显著负相关性(Cys C:r=-0.823,P﹤0.001;SCr:r=-0.563,P﹤0.001)。ROC曲线分析显示Cys C的曲线下面积(AUC)值明显高于SCr(0.863vs0.601)。结论 Cys C较SCr能更为准确和迅速地反映过敏性紫癜患者的肾功能损害;常规监测该类患者的Cys C水平,对有效防治过敏性紫癜导致的肾功能损伤具有积极意义。
Objective To investigate the significance of detecting serum Cystatin C in early detection of renal dysfunction in patients with allergic purpura. Methods The serum creatinine (24hr), serum creatinine (SCr) and serum Cystatin C (Cys C) levels were measured in 83 patients with allergic purpura. Chi-square test, correlation analysis and ROC curve analysis of CysC diagnostic value. Results Of the 83 patients, 32 cases had a decrease in CCr, of which 27 cases were elevated in Cys C level, while only 13 cases showed abnormal SCr. Cys C was superior to SCr in assessing CCr (P <0.05). Correlation analysis indicated that there was a significant negative correlation between Cys C and SCr and CCr in patients with HSP (Cys C: r = -0.823, P < 0.001; SCr: r = -0.563, P <0.001). ROC curve analysis showed that the area under the curve (AUC) of Cys C was significantly higher than that of SCr (0.863 vs 0.601). Conclusion Cys C can reflect the renal dysfunction of patients with allergic purpura more accurately and quickly than SCr. Routine monitoring of Cys C level in this group of patients has positive significance in the prevention and treatment of renal dysfunction caused by Henoch-Schonlein purpura.