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应用马利兰治疗慢性粒细胞白血病(简称慢粒)已有25年以上的历史。通常每天服用马利兰2～6毫克,诱导缓解是长的。但骨髓细胞仍增生明显;伴有大量分裂细胞保留着Ph~1染色体;周围血象中不成熟细胞持续存在,脾肿大可不完全消退,更为危险的是在某些病人中有难以预料的严重的骨髓抑制。一般认为大剂量马利兰的毒性作用较大,其机理是有争论的;其毒性与剂量、治疗时间的长短有关。因此,一次剂量,适当的间歇期,可以控制细
The application of Maryland treatment of chronic myeloid leukemia (referred to as CML) for more than 25 years of history. Usually take 2 to 6 mg of marilan daily, induced remission is long. However, the myeloid cells still proliferate obviously. With a large number of dividing cells, the Ph ~ 1 chromosome is retained. The immature cells in the peripheral blood are persisted and the splenomegaly may not completely subside. What is more dangerous is the unpredictability in some patients Myelosuppression. It is generally believed that the toxic effects of large doses of marilan greater, the mechanism is controversial; its toxicity and dose, the length of treatment time. Therefore, a dose, the appropriate intermittent period, you can control the fine