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目的:考查动物灌胃给予鼻力宝胶囊的急性毒性和长期毒性。方法:参照Bliss法。大鼠分鼻力宝胶囊高、中、低剂量组,对照组,连续灌胃4周,停药恢复期2周。观察实验期间大鼠的行为活动、外观体征、体重、摄食量的变化,给药末和恢复期末两次解剖,检测血液常规、血液生化、脏器系数。观察组织器官病理学变化。结果:鼻力宝胶囊半数致死量为128.8g/kg,95%平均可信限:119.3~139.1g生药/kg;长期毒性实验,鼻力宝胶囊对大鼠经口给药的高剂量为鼻力宝胶囊相当于生药30g/(kg·d),无明显毒性反应。结论:鼻力宝胶囊安全可靠。
OBJECTIVE: To investigate the acute toxicity and long-term toxicity of nasal pill by intragastric administration to animals. Method: Refer to Bliss method. Rats points nasal Bao Capsule high, medium and low dose groups, the control group, continuous gavage for 4 weeks, stopping the recovery period of 2 weeks. Observed during the experiment behavioral activities, appearance and signs, body weight, food intake changes, the end of the administration and the end of recovery two anatomical, blood routine examination, blood biochemistry, organ coefficient. Observe the histopathological changes of tissues and organs. Results: The half dose lethal dose was 128.8g / kg and the 95% average confidence limit was 119.3 ~ 139.1g crude drug / kg. Long-term toxicity test: Lippo capsule equivalent to crude drug 30g / (kg · d), no significant toxicity. Conclusion: Neroli capsule is safe and reliable.