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硝苯吡啶(N)对窦房结(SN)有直接抑制作用;还有使周围血管阻力减少而通过交感神经系统调节的间接作用,而提高SN自主节律和改进房室(A-V)结传导.在正常情况下,这种间接作用比直接作用强,因此可使心率轻微或明显地增加。本研究观察15例病态窦房结综合征(SSS)患者用N后其SA和A-V结的变化。方法;15例SSS患者(男9例、女6例),年龄62—76岁,平均68.1岁。其中8例有反复晕厥发作,7例有头晕发作。SSS诊断标准是:心率<50次/分,窦性静止或窦房阻滞大于2个窦性周期长度。4例患者有缓慢房率,ECG可见Ⅱ、Ⅳ、aVF、V_5、V_4呈倒P而aVR是直立P,6例系慢一快综合征。临床特点是反复发作的室上速和缓慢型
Nifedipine (N) has a direct inhibitory effect on the sinus node (SN); it also decreases the peripheral vascular resistance and increases the autonomic rhythm of the SN and atrioventricular (AV) node conduction via indirect effects of the sympathetic nervous system. Under normal circumstances, this indirect effect than direct action, so you can make a slight or significant increase in heart rate. In this study, 15 patients with sick sinus syndrome (SSS) patients with N after SA and A-V junction changes. Methods Fifteen SSS patients (9 males and 6 females) aged 62-76 years, mean 68.1 years. Eight of them had recurrent seizures and seven had dizziness. SSS diagnostic criteria are: heart rate <50 beats / min, sinus arrest or sinoatrial block more than 2 sinus cycle length. 4 patients had slow room rate, ECG shows Ⅱ, Ⅳ, aVF, V_5, V_4 was inverted P and aVR is upright P, 6 cases of slow-fast syndrome. Clinical features are recurrent supraventricular tachycardia and slow type