论文部分内容阅读
对219例慢性肾小球肾炎尿毒症（CGN）病人和406例健康人群进行HLA免疫基因的频率、单倍型频率分析和疾病关联研究。结果：在疾病组中HLA－B13、B35、B55、DR7、DR10、DR12、DQ7对基因频率和A11－B60、A11－DR10、A11－DR12、A11－DQ7、A24－DR14、DR10－B60、DR10－DQ7、DR12－DQ7单倍型频率显著升高，B46－DQ9显著降低，RR均＞3．84，P均＜0．05。提示HLA免疫基因与易感GN之间强关联，是最终导致肾功能衰竭的风险因素，其中B55、DR10、DQ7为国内外相关研究中首次报道，可能是疾病人群特有的地区性风险因子。
219 cases of chronic glomerulonephritis uremic (CGN) patients and 406 healthy people HLA immune gene frequency, haplotype frequency analysis and disease association studies. Results: The frequencies of HLA-B13, B35, B55, DR7, DR10, DR12, DQ7 pairs of genes in the disease group and the A11-B60, A11- DR10, A11- DR12, A11- DQ7, A24- DR14, DR10- B60, DR10 -DQ7, DR12-DQ7 haplotype frequency was significantly increased, B46-DQ9 significantly reduced, RR was> 3.84, P <0.05. Suggesting that the strong association between HLA immune genes and susceptible GN is the risk factor of renal failure. B55, DR10 and DQ7 are the first reported in related studies both at home and abroad, which may be endemic regional risk factors for disease patients.