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白介素 1(ＩＬ 1)是在免疫和炎症反应中起核心作用的细胞因子[1] 。核因子 κＢ (ＮＦ κＢ )和ＡＰ 1被越来越多的研究证明为调控ＩＬ 1刺激炎症因子表达的主要转录因子[2～ 4 ] 。因此 ,阐明ＩＬ 1激活ＮＦ κＢ和ＡＰ 1的机制具有重要的理论和临床应用价值。最近发现 ,Ｉ
Interleukin 1 (IL 1) is a cytokine that plays a central role in immune and inflammatory responses [1]. A growing number of studies have demonstrated that NF-κB (NF κB) and AP 1 are the major transcription factors that regulate IL-1-stimulated expression of inflammatory cytokines [2-4]. Therefore, elucidating the mechanism of IL-1 activation of NF-κB and AP 1 has important theoretical and clinical value. Recently discovered, I