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目的研究原发性高血压患儿血液流变学变化,并探讨其临床意义。方法选取37例原发性高血压患儿(高血压组)。男19例,女18例;年龄(12.49±3.20)岁。对其血液流变学及血脂、血糖等实验室参数进行检测,并与30例年龄匹配的健康儿童相应参数作对照分析。应用SPSS 11.5软件进行统计学分析。结果高血压组全血黏度低切、全血黏度中切、全血黏度高切、血浆黏度、红细胞比容、红细胞刚性指数、血小板聚集率M均显著高于健康对照组(Pa<0.05),红细胞电泳指数则显著低于健康对照组(P<0.05)。高血压组患儿血糖、三酰甘油、总胆固醇、低密度脂蛋白较健康对照组儿童升高,而高密度脂蛋白降低,但其差异均无统计学意义(Pa>0.05)。结论高血压患儿血液流变学有明显改变,可能对儿童原发性高血压发病机制有一定作用。
Objective To study the changes of hemorheology in children with essential hypertension and to explore its clinical significance. Methods 37 children with essential hypertension (hypertension group) were selected. 19 males and 18 females; age (12.49 ± 3.20) years old. The hemorrheology, blood lipid, blood glucose and other laboratory parameters were detected and compared with the corresponding parameters of 30 age-matched healthy children. SPSS 11.5 software was used for statistical analysis. Results The whole blood viscosity cut, whole blood viscosity cut, plasma viscosity, hematocrit, erythrocyte rigidity index and platelet aggregation rate M in hypertension group were significantly higher than those in healthy control group (P <0.05) Erythrocyte electrophoresis index was significantly lower than the healthy control group (P <0.05). Blood pressure, triglyceride, total cholesterol, low density lipoprotein in hypertensive children were higher than those in healthy children, but high density lipoprotein was lower in children with hypertension, but there was no significant difference (P> 0.05). Conclusion There is a significant change in the hemorheology of hypertensive children, which may have some effect on the pathogenesis of essential hypertension in children.