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设计合成了 11个含有Schiff碱双键的酚取代双膦酸酯类化合物 .对小鼠白血病细胞P388、人肺腺癌细胞A 5 49的体外抗癌活性实验表明 :目标分子中酚羟基的位置对化合物的活性有着重要影响 ,当酚羟基位于Schiff碱双键的邻位时 ,其活性明显高于其他化合物
We designed and synthesized eleven phenolic substituted biphosphonates with Schiff base double bonds.The in vitro anticancer activity of mouse leukemia cell line P388 and human lung adenocarcinoma cell line A 5 49 showed that the position of phenolic hydroxyl group in the target molecule The activity of compounds has an important impact, when the phenolic hydroxyl in the Schiff base double bond ortho position, its activity was significantly higher than other compounds