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目的探讨2型糖尿病患者肺功能改变及相关因素,为糖尿病肺损伤的预防和保护提供参考依据。方法选取2型糖尿病患者及健康体检者各57例,抽取清晨空腹血,测定两组患者糖化血红蛋白(Hb A1c)、空腹血糖(FPG)及空腹胰岛素(FINS)水平,计算胰岛素抵抗指数(HOMA-IR)。测定两组人群肺通气功能和弥散功能,记录观察组体重指数(BMI)、病程及并发症积分。结果观察组患者肺通气功能指标FEV1、FVC、FEV1%低于对照组(P<0.05),肺弥散功能指标DLCO、KCO低于对照组(P<0.01);患者的病程、Hb A1c以及微血管并发症积分与肺功能改变相关(P<0.05)。结论 2型糖尿病患者可存在肺通气和弥散功能障碍,且随着病程延长、Hb A1c水平升高以及其他并发症,肺功能受损率增加,应积极控制血糖有利于避免肺功能受损。
Objective To investigate the changes of lung function and related factors in type 2 diabetic patients and provide references for the prevention and protection of diabetic lung injury. Methods Fifty-seven patients with type 2 diabetes mellitus and healthy subjects were enrolled in this study. Fasting blood samples were taken early in the morning to determine the levels of Hb A1c, fasting blood glucose (FPG) and fasting insulin (FINS) in both groups. HOMA- IR). Pulmonary ventilation and diffusive function were measured in two groups. Body mass index (BMI), course of disease and complications were recorded. Results The pulmonary function parameters FEV1, FVC and FEV1% in the observation group were lower than those in the control group (P <0.05), and the indexes of DLCO and KCO in the pulmonary function were lower than those in the control group (P <0.01). The duration of the disease, Hb A1c and microvascular complications Syndromes were associated with changes in lung function (P <0.05). Conclusions Patients with type 2 diabetes mellitus may have pulmonary ventilation and diffuse dysfunction. With prolonged course of disease, elevated Hb A1c levels and other complications, and increased pulmonary function impairment, positive control of blood glucose should be helpful to avoid impaired pulmonary function.