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目的 探讨腹腔镜与开腹手术治疗卵巢良性畸胎瘤的疗效以及对患者免疫功能的影响.方法 选取2015年2月-2017年3月来吉林医药学院附属医院就诊的卵巢良性肿瘤行开腹手术患者与腹腔镜手术患者各40例,检测术前24 h、术后24 h、术后72 h外周血白细胞介素-18(IL-18)及T淋巴细胞亚群CD4+/CDs+水平,将两种方式的手术时间、患者出血量、术后排气时间进行对比.结果 ①术后24、72 h两组IL-18水平均高于术前(P＜0.05),且术后24h上升明显(P＜0.01),术后72 h下降,下降程度显著低于腹腔镜组(P＜0.05),腹腔镜组患者在手术后72 h的恢复程度接近术前水平;②术后24、72 h两组T淋巴细胞亚群CD4 +/CDs+均有所下降,且术后24h下降明显(P＜0.05),术后72 h有所上升,程度显著低于腹腔镜组(P＜0.05),腹腔镜组患者在手术后72 h的恢复程度接近术前水平;③两组相比,腹腔镜组患者的手术时间短、手术出血量少、术后排气早(P＜0.01).结论 对于卵巢良性畸胎瘤患者采用腹腔镜手术治疗的效果好,对细胞和体液免疫产生的影响均较小,对机体损伤小,术后修复快.“,”Objective To explore the curative effects of laparoscopic surgery and laparotomy in treatment of ovarian benign teratoma and the influence on immune function.Methods Forty patients with ovarian benign tumors were treated by laparoscopic surgery in the hospital from February 2015 to March 2017,and forty patients with ovarian benign tumors were treated by laparotomy during the same period,the levels of interleukin-18 (IL-18) and T lymphocyte subset CD4+/CD8+ in peripheral blood were detected at 24 hours before operation,24 and 72 hours after operation.The operation time,the amount of bleeding,and the time of postoperative exhaust were compared between the two methods.Results The levels of IL-18 at 24 and 72 hours after operation in the two groups were statistically significantly higher than those before operation (P＜0.05),which increased significantly at 24 hours after operation (P＜0.01) and decreased at 72 hours after operation,and the degree of decrease was statistically significantly lower than that in laparoscopic surgery group (P＜0.05).The recovery degree of the patients in laparoscopic surgery group was close to the preoperative level at 72 hours after operation.The levels of T lymphocyte subset CD4+/CD8+ at 24 and 72 hours after operation in the two groups decreased,which decreased significandy at 24 hours after operation (P＜0.05) and increased at 72 hours after operation,and the degree of increase was significantly lower than that in laparoscopic surgery group (P＜0.05).The recovery degree of patients in laparoscopic surgery group was close to the preoperative level at 72 hours after operation.The patients in laparoscopic surgery group had shorter operation time,less bleeding,and earlier postoperative exhaust compared with laparotomy group (P＜0.01) Conclusion For patients with ovarian benign teratoma,laparoscopic surgery is effective,which has less influence on cellular immunity and humoral immunity,less damage to the body and faster postoperative repair capability.