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目的 从免疫与糖代谢的关系方面探讨儿童肥胖症的发病机制。 方法 对５２ 例肥胖儿童及４０例正常儿童进行血糖、胰岛素、抗胰岛素抗体水平及葡萄糖耐量试验的检测对比分析。 结果 肥胖组血胰岛素水平和抗胰岛素抗体水平与对照组比较差异有非常显著意义（ Ｐ＜ ０ ．０１） ；肥胖儿童葡萄糖耐量试验呈延迟反应。 结论 肥胖儿童的胰岛素抵抗与抗胰岛素抗体水平有关。
Objective To explore the pathogenesis of childhood obesity from the relationship between immune and glucose metabolism. Methods Fifty-two obese children and 40 normal children underwent blood glucose, insulin, anti-insulin antibody levels and glucose tolerance test comparative analysis. Results The level of insulin and anti-insulin antibody in obese group was significantly different from that in control group (P <0.01). The glucose tolerance test in obese children was delayed. Conclusion The insulin resistance in obese children is related to the level of anti-insulin antibody.