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目的探讨亚甲基四氢叶酸还原酶(MTHFR)C677T位点与胃癌、大肠癌、肺癌患者易感性的关系。方法对139例胃癌患者,141例大肠癌患者,120例肺癌患者和165例的正常对照者,利用Sequenom Iplex系统检测MTHFR C677T位点基因多态性。结果胃癌组和对照组MTHFR基因C677T各基因型的分布差异无显著性,但P值接近0.05(2=4.96,P=0.08),大肠癌组及肺癌组和对照组C677T基因型的分布差异无显著性,P值分别为0.81和0.85。结论 MTHFR基因C677T在胃癌和正常人之间有所不同,有助于从分子遗传学角度早期发现胃癌的易感人群,未发现C677T和大肠癌及肺癌的相关性。
Objective To investigate the relationship between the methylenetetrahydrofolate reductase (MTHFR) C677T locus and susceptibility to gastric cancer, colorectal cancer and lung cancer. Methods The sequence of MTHFR C677T gene polymorphism was detected by Sequenom Iplex system in 139 gastric cancer patients, 141 colon cancer patients, 120 lung cancer patients and 165 normal controls. Results There were no significant differences in the distribution of MTHFR C677T genotype between gastric cancer group and control group, but the P value was close to 0.05 (2 = 4.96, P = 0.08). There was no significant difference in the distribution of C677T between the colorectal cancer group, lung cancer group and control group Significance, P values were 0.81 and 0.85, respectively. Conclusions The C677T gene of MTHFR is different between gastric cancer and normal people, which is helpful for early detection of gastric cancer in molecular genetics. No correlation was found between C677T and colorectal cancer and lung cancer.