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肥厚梗阻型心肌病(Hypertrophic obstructive cardiomyopathy,HOCM)是一种原因不明的心肌疾病,它的基本病理特征是心肌非对称性肥厚,心室腔变小,左心室血液充盈受限,左室舒张期顺应性下降及晚期传导系统受累。传统药物治疗主要包括β受体阻滞剂、钙拮抗剂和胺碘酮等,长期治疗后不良反应较大,如心源性猝死、肺水肿及传导障碍等,故病人不能耐受,且疗效难以预测。1982年3月～2000年4月,我们以环磷酸腺苷葡甲胺(心先安)治疗HOCM16例,其近期疗效令人满意,现报告如下。
Hypertrophic obstructive cardiomyopathy (HOC) is an unknown cause of myocardial disease, its basic pathological features of myocardial asymmetry hypertrophy, ventricular cavity smaller, limited left ventricular filling, left ventricular diastolic compliance Sexual decline and advanced conduction system involvement. Traditional drug therapy, including β-blockers, calcium antagonists and amiodarone, long-term treatment of adverse reactions, such as sudden cardiac death, pulmonary edema and conduction disorders, so the patient can not tolerate, and the effect Unpredictable From March 1982 to April 2000, we treated 16 cases of HOCM with adenosine monophosphate (AMI), and its recent curative effect is satisfactory. The report is as follows.