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目的对糖尿病早期肾病患者血浆中凝血因子Ⅺ氧化还原状态分析研究。方法 101例糖尿病早期肾病患者,按照尿蛋白排泄率分成微量白蛋白尿组(DM+MAU组,50例)和非微量白蛋白尿组(DM+NAU组,51例),50例健康人群作为正常的对照组。测定各组24 h中各患者的血糖、血脂、凝血指标以及血浆还原型Ⅺ的相对水平,采用尿白蛋白排泄率(UAER)为变量的形式,与相关指标结合,进行多元素的同步回归分析。结果 DM+NAU组和DM+MAU组的血浆还原型Ⅺ相对水平高于对照组,差异有统计学意义(P<0.05),DM+MAU组的血浆还原型Ⅺ的水平与DM+NAU组比较明显增高,差异有统计学意义(P<0.05)。结论血浆还原型Ⅺ的水平明显增加与患者MAU具有联系,能够加速血液的循环,加重对血浆与肾脏的危害,导致重症MA的出现。
Objective To study the plasma redox state of coagulation factor Ⅺ in patients with early diabetic nephropathy. Methods 101 patients with early diabetic nephropathy were divided into microalbuminuria group (DM + MAU group, 50 cases) and non-microalbuminuria group (51 cases) according to urinary protein excretion rate, 50 healthy people Normal control group. The levels of blood glucose, blood lipids, blood coagulation and the relative levels of plasma-reduced Ⅺ in each group were measured at 24 h. The urinary albumin excretion rate (UAER) was used as a variable in combination with related indicators to perform simultaneous regression analysis of multiple elements . Results The relative plasma levels of XI in DM + NAU group and DM + MAU group were significantly higher than those in control group (P <0.05). The plasma levels of XI in DM + MAU group were significantly lower than those in DM + NAU group Was significantly higher, the difference was statistically significant (P <0.05). Conclusions The marked increase of plasma reduced type Ⅺ can be linked with MAU of patients, which can accelerate blood circulation, aggravate the damage to plasma and kidney, and lead to the emergence of severe MA.