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本研究的目的在于观察烟碱诱发大鼠惊厥耐受形成的特点．烟碱急性给药（２．０，３．５和５．０ｍｇ·ｋｇ－１ｓｃ）产生的惊厥具有剂量依赖性；美加明可完全对抗，但六甲溴胺不能使之缓解．烟碱（２．０，３．５和５．０ｍｇ·ｋｇ－１）连续１２ｄｓｃ后，ｄ１３给予一较小剂量（１．８ｍｇ·ｋｇ－１ｓｃ）激发，可观察到由于激发给药使耐受进一步形成．在激发给药１５ｍｉｎ后，取大鼠血及几个脑区组织，测定血清及脑组织匀浆中烟碱含量，实验显示各脑区烟碱含量也具有剂量依赖性，而血清烟碱维持在相同水平．这些结果表明：烟碱连续给药后诱发大鼠惊厥耐受性可在较早的几天内迅速产生，且与脑组织烟碱水平密切相关．
The purpose of this study was to observe the characteristics of nicotine-induced convulsion tolerance in rats. Convulsions produced by acute administration of nicotine (2.0, 3.5 and 5.0 mg · kg-1sc) were dose-dependent; mecamylamine was completely antagonistic but hexamethonium did not attenuate it. Administration of nicotine (2.0, 3.5 and 5.0 mg · kg-1) for 12 days followed by a small dose (1.8 mg · kg-1sc) of d13 provoked an increase in tolerance Further formed. After stimulated for 15 min, rat blood and several brain tissues were taken for determination of nicotine content in serum and brain tissue homogenates. Experiments showed that nicotine content in each brain region was also dose-dependent while serum nicotine was maintained at The same level. These results indicate that convulsant tolerance induced by continuous administration of nicotine in rats can be rapidly produced in the earlier days and is closely related to nicotine levels in brain tissues.