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前人研究显示,他汀类药物对室性心律失常具有良好的保护作用。但Rahimi等最近指出,他汀类药物仅能在一定程度上降低心源性猝死风险,且其疗效远没有预期好。该研究通过对已发表的随机试验数据进行meta分析,探讨了他汀类药物是否能减少室性心律失常、心脏骤停及心脏性猝死的风险。通过检索MEDLINE、EMBASE及CENTRAL,筛选出截至2010年10月有关他汀和非他汀类药物的随机对照研究,以及他汀常规剂量和加大剂量的随机对照研究,要求入选的研究样本量>100名,且
Previous studies have shown that statins have a good protective effect on ventricular arrhythmias. However, Rahimi et al recently pointed out that statins can only reduce the risk of sudden cardiac death to a certain extent, and its efficacy is far from expected. In a meta-analysis of published randomized trial data, the study examined whether statins reduce the risk of ventricular arrhythmias, cardiac arrest, and sudden cardiac death. By searching MEDLINE, EMBASE and CENTRAL, randomized controlled trials of statins and non-statins as of October 2010 and randomized controlled studies of conventional and statinized doses of statins were screened. The required sample sizes were> 100, And