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应用推挽灌流技术，研究清醒，自由活动大鼠下丘脑后部内源性氨基酸神经递质γ－氨基丁酸（ＧＡＢＡ），牛磺酸（Ｔａｕ），谷氨酸（Ｇｌｕ）和５－羟色胺（５－ＨＴ）的释放，观察某些影响神经元活动的药物和改变外周血流动力学时对它们释放的影响。结果表明，在正常条件下。连续观察６ｈ．其基础释放相对恒定，用高Ｋ＋（５０．９０ｍｍｏｌ·Ｌ－１）人工脑脊液灌流。释放依剂量增加，藜芦定碱（１，１０μｍｏｌ·Ｌ－１）有类似作用；河豚毒素（１μｍｏｌ·Ｌ－１）可使ＣＡ８Ａ，Ｔａｕ和５－ＨＴ释放减少，对Ｇｌｕ的释放影响较弱。外周血流动力学改变对ＧＡＢＡ。Ｔａｕ和Ｇｌｕ的释放均可产生明显的影响。血管阻力和血容量增加血压上升时。ＧＡＢＡ。Ｔａｕ和Ｇｌｕ释放明显增加：血管扩张和血容量减少时。ＧＡＢＡ。Ｔａｕ的释放减少。而Ｇｌｕ的释放则增加。结果提示。下丘脑后部ＣＡＢＡ，Ｔａｕ和Ｇｌｕ作为神经递质。可能参与外周动脉血压的调节．
Using push-pull technique, the effects of endogenous amino acid neurotransmitters GABA, Tau, Glu and 5-HT in conscious and freely moving rats 5-HT) release to observe the effects of certain drugs that affect neuronal activity and their effects on the release of peripheral hemodynamics. The results show that under normal conditions. Continuous observation 6h. The basal release was relatively constant, with high K + (50.90mmol·L-1) artificial cerebrospinal fluid perfusion. Release of verapamil (1, 10μmol·L-1) had a similar effect. Tetrodotoxin (1μmol·L-1) decreased the release of CA8A, Tau and 5-HT, but had less effect on the release of Glu . Peripheral hemodynamic changes to GABA. Tau and Glu release can have a significant impact. Vascular resistance and blood volume increase when blood pressure rises. GABA. Tau and Glu release significantly increased: vasodilation and decreased blood volume. GABA. Tau release reduced. Glu release increased. The results suggest. Hypothalamic posterior CABA, Tau and Glu act as neurotransmitters. May participate in the regulation of peripheral arterial pressure.