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以长时期（共7周）大强度跑台运动（速度由15m／min递增至35m／min，运动时间为20～25min／d）制造大鼠疲劳模型，探索疲劳大鼠外周阿片肽的变化及中药复方的作用机理。结果表明：运动后即刻血乳酸显著高于对照组，血浆β-内啡肽、强啡肽A1-13含量显著下降，而亮氨酸脑啡肽变化不明显；经中药复方治疗后，上述变化均有不同程度的恢复。表明此运动强度下的疲劳大鼠，内源性阿片肽系统受抑制而使外用血中的β-内啡肽、强啡肽A1-13含量下降；中药复方作用后激活了此系统，主要使卜内啡肽水平升高，并对血乳酸有一定的清除作用，从而有利于消除疲劳。
Long-term (a total of 7 weeks) high-intensity treadmill exercise (the speed was increased from 15m/min to 35m/min, exercise time was 20-25min/d) was used to create a rat fatigue model to explore the changes of peripheral opioid peptides in fatigue rats. Mechanism of Action of Chinese Herbal Compounds. The results showed that blood lactate was significantly higher than that of the control group immediately after exercise, and plasma β-endorphin and dynorphin A1-13 levels were significantly decreased, while leucine-enkephalin was not changed significantly; after treatment with traditional Chinese medicine compound, the above changes were observed. All have different degrees of recovery. It was shown that in rats with fatigue under this exercise intensity, endogenous opioid peptide system was inhibited and the contents of β-endorphin and dynorphin A1-13 in blood for external use were decreased. After activation of traditional Chinese medicine compound, the system was activated. The level of gopoorine is elevated, and there is a certain clearance of blood lactic acid, which is beneficial to eliminate fatigue.