静脉注射普鲁卡因及芬太尼对外侧网状核神经元伤害性反应的影响

• 作 者: 陆康生 曾因明 赵志奇
• 机 构: 徐州医学院江苏省麻醉学重点实验室!225001扬州大学医学院附院麻醉科,徐州医学院江苏省麻醉学重点实验室!225001,中国科学院上海脑研究所
• 出 处: 中华麻醉学杂志
• 发表日期: 1999年04期
• 关键词: 外侧网状核 伤害性 疼痛感受器 镇痛作用 高级中枢 抑制作用 腓肠神经 强度刺激 抑制效应 脑立体定位仪

目的　观察静脉注射普鲁卡因及芬太尼对外侧网状核神经元伤害性反应的影响，以探讨其镇痛作用是否有脑的高级中枢的参与。方法　应用细胞外微电极记录的方法，在Ｗｉｓｔａｒ大鼠观察静脉注射普鲁卡因（１０ｍ ｇ／ｋｇ）及芬太尼（１、２、５ 和１０μｇ／ｋｇ）对Ｃ强度刺激腓肠神经诱发的外侧网状核神经元伤害性反应的影响。结果　静脉注射普鲁卡因对测试的７ 个单位的神经元伤害性反应均呈抑制作用，平均最大抑制为３６６％ （Ｐ＜ ００１），芬太尼对所有被观察的２４ 个神经元产生了抑制作用，平均抑制分别为２９０％ 、７５６％ 、６３９％ 和７１８％ ，均具有显著性差异，此效应并被静脉注射纳络酮（０５ｍ ｇ／ｋｇ）完全逆转。在２ 个芬太尼产生抑制的单位，静脉注射普鲁卡因也产生了抑制效应。结论　外侧网状核神经元与痛觉的传导及调制有关，脑的高级中枢也参与了静脉注射普鲁卡因及芬太尼产生的镇痛作用

Objective To observe the effect of intravenous procaine and fentanyl on the nociceptive reaction of neurons in the reticular nucleus in order to find out whether the analgesic effect involves the involvement of the higher central nervous system. Methods Extracellular microelectrode recording was used to observe the effects of intravenous injection of procaine (10 m g / kg) and fentanyl (1, 2, 5 and 10 μg / kg) on ​​the C intensity-stimulated sural nerve in Wistar rats Of the outer reticular nucleus neurons. Results Intravenous injection of procaine inhibited neuronal nociceptive response in all seven units tested, with an average maximum inhibition of 36.6% (P <001). Fentanyl was also effective against all 24 observed The inhibitory effect of neurons was found. The average inhibition was 290%, 756%, 639% and 718%, respectively. There was a significant difference between the two groups. This effect was also induced by intravenous injection of naloxone g / kg) completely reversed. Intravenous procaine also produced an inhibitory effect in the two units where inhibition of fentanyl occurred. CONCLUSIONS: The neurons in the lateral reticular nucleus are associated with the conduction and modulation of pain sensation. The higher centers of the brain are also involved in the analgesic effect of intravenous procaine and fentanyl