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采用放射免疫法测定正常人及子宫内膜异位症患者在位、异位子宫内膜培养细胞6-酮-PGF_(1a)和 TXB_2的含量,并观察醋酸棉酚、孕酮、丹那唑及 GnRHa 作用于实验细胞后前列腺素含量的变化。结果表明,患者在位、异位子宫内膜培养细胞6-酮-PGF_(1a)和TXB_2含量高于正常人,除 GnRHa 外,醋酸棉酚等三药使患者在位、异位子宫内膜培养细胞6-酮-PGF_(1a)或/和 TXB_2含量降低。提示前列腺素与子宫内膜异位症的病理生理变化有关,药物对前列腺素的直接抑制作用是抗子宫内膜异位症机制之一。
Radioimmunoassay was used to determine the contents of 6-keto-PGF(1a) and TXB_2 in eutopic and ectopic endometrium cultures in normal and endometriosis patients, and the gossypol, progesterone acetate, and danazol were observed. Changes in prostaglandin levels after treatment with GnRHa in experimental cells. The results showed that the contents of 6-keto-PGF(1a) and TXB_2 in patients with ectopic endometrium and endometriosis were higher than those in normal subjects. In addition to GnRHa, three drugs such as gossypol acetate made the patient’s ectopic and ectopic endometrium. The content of 6-keto-PGF_(1a) or/and TXB_2 in cultured cells decreased. Prostaglandins are associated with the pathophysiological changes of endometriosis. The direct inhibition of prostaglandins by drugs is one of the mechanisms of resistance to endometriosis.