论文部分内容阅读
脑信号蛋白(Semaphorins)最初被发现作为轴突导向因子参与神经系统发育。Semaphorins家族是一类结构中具有sema结构域为共同特征的蛋白。目前发现脑信号蛋白家族共有20多个成员,分为8个亚类,其中:Ⅰ和Ⅳ~Ⅶ亚类为膜型蛋白,Ⅱ、Ⅲ和Ⅷ亚类为分泌型蛋白。脑信号蛋白除了在神经系统发育、心脏发生、血管及破骨细胞生成等生理方面发挥作用,同时还参与多种疾病发生,包括肿瘤发生及转移,神经退行性变和猝死等。目前越来越多的证
Semaphorins were originally found to be involved in the development of the nervous system as axon guidance factors. The Semaphorins family is a family of proteins that share the same sema domain structure. Currently, there are more than 20 members of the brain signal protein family, which are divided into eight subtypes. Among them, subtypes I and IV to VII are membrane proteins, and subtypes II, III and VIII are secretory proteins. Brain signal proteins not only play a role in the physiological development of the nervous system, cardiac, blood vessels and osteoclastogenesis, but also participate in a variety of diseases, including tumorigenesis and metastasis, neurodegeneration and sudden death. At present more and more evidence